Overview

  • Product nameAnti-DP1 antibody
    See all DP1 primary antibodies
  • Description
    Rabbit polyclonal to DP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 360-409 (SASDLTNGAD GMLATSSNGS QYSGSRVETP VSYVGEDDEE DDDFNENDED) of Human DP1 (NP_009042).

  • Positive control
    • Human fetal spleen lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCan stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.
  • Tissue specificityHighest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
  • Sequence similaritiesBelongs to the E2F/DP family.
  • Post-translational
    modifications
    Phosphorylation by E2F-1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DP 1 antibody
    • DP1 antibody
    • DRTF1 antibody
    • DRTF1-polypeptide 1 antibody
    • E2F dimerization partner 1 antibody
    • E2F related transcription factor antibody
    • TFDP1 antibody
    • TFDP1_HUMAN antibody
    • Transcription factor Dp-1 antibody
    • Transcription factor sequence-specific, DRTF1 antibody
    see all

Anti-DP1 antibody images

  • Anti-DP1 antibody (ab90309) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µg

    Secondary
    HRP conjugated anti-rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa

References for Anti-DP1 antibody (ab90309)

ab90309 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab90309.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"