Overview

  • Product name
  • Description
    Rabbit polyclonal to DPM1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Xenopus laevis, A wide range of other invertebrates
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-168 of the Human DPM1 protein (O60762).

  • Positive control
    • NT2D1, U87-MG and MCF-7 cell lysates

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 30 kDa.

Target

  • Function
    Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in DPM1 are the cause of congenital disorder of glycosylation type 1E (CDG1E) [MIM:608799]. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1E is an autosomal recessive disorder, characterized by severe developmental delay, hypotnia, seizures, and dysmorphic features.
  • Sequence similarities
    Belongs to the glycosyltransferase 2 family.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDGIE antibody
    • dolichol monophosphate mannose synthase antibody
    • Dolichol phosphate mannose synthase antibody
    • Dolichol-phosphate mannose synthase antibody
    • Dolichol-phosphate mannosyltransferase antibody
    • Dolichyl phosphate beta D mannosyltransferase antibody
    • dolichyl phosphate mannosyltransferase polypeptide 1 antibody
    • dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit antibody
    • Dolichyl-phosphate beta-D-mannosyltransferase antibody
    • DPM synthase antibody
    • DPM1 antibody
    • DPM1_HUMAN antibody
    • Mannose P dolichol synthase antibody
    • Mannose-P-dolichol synthase antibody
    • MPD synthase antibody
    • MPDS antibody
    see all

Images

  • Anti-DPM1 antibody (ab126092) at 1/1000 dilution + U87-MG whole cell lysate at 30 µg

    Predicted band size : 30 kDa

References

ab126092 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab126092.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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