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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Overview
Product name
Anti-DPP10 antibody - Catalytic domain
See all DPP10 products (7) ...
Description
Rabbit polyclonal to DPP10 - Catalytic domain
Specificity
This antibody recognises all four forms of DPP10. This antibody does not recognise other DPP family members.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide corresponding to the catalytic domain of human DPP10.
(Peptide available as ab44606.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 0.5M Sodium chloride
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
This antibody recognises all four forms of DPP10.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> DPPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Applications
Show applications key
Our Abpromise guarantee covers the use of ab42084 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/1000 - 1/5000. Predicted molecular weight: 91 kDa. Recommended starting dilution 1/1000 for colourimetric substrates, 1/5000 for chemiluminescent substrates. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.
Tissue specificity
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
Involvement in disease
Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
Sequence similarities
Belongs to the peptidase S9B family. DPPIV subfamily.
Post-translational
modifications
N-glycosylated.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ8N608
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Dipeptidyl peptidase like protein 2 antibody
- DPPY antibody
- Dipeptidyl peptidase 10 antibody
see all
Database links
- Entrez Gene: 57628 Human
- Entrez Gene: 269109 Mouse
- Entrez Gene: 363972 Rat
- Omim: 608209 Human
- SwissProt: Q8N608 Human
- SwissProt: Q6NXK7 Mouse
- SwissProt: Q6Q629 Rat
- Unigene: 176247 Human
see all
Protocols
References for Anti-DPP10 antibody - Catalytic domain (ab42084)
ab42084 has not yet been referenced specifically in any publications.
Publishing research using ab42084? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"