Human Predicted to work with:
Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig, Monkey, Gorilla
Synthetic peptide within Human DPP10. The exact sequence is proprietary. Synthetic peptide corresponds to 14 amino acids of the extracellular domain. (NCBI Accession No. NP_065919.2) Database link: Q8N608
Human brain tissue m(cerebellum Purkinje neurons).
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
Involvement in disease
Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
Belongs to the peptidase S9B family. DPPIV subfamily.