Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab41809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 98 kDa. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceDPP6 (DPPX, also known as potassium channel accelerating factor Dppx) is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.
    • Cellular localizationCell Membrane; single-pass type II membrane protein
    • Database links
    • Alternative names
      • Dipeptidyl aminopeptidase IV related protein antibody
      • Dipeptidyl aminopeptidase like protein 6 antibody
      • Dipeptidyl aminopeptidase related protein antibody
      • Dipeptidyl peptidase 6 antibody
      • Dipeptidyl peptidase IV like protein antibody
      • Dipeptidyl peptidase IV related protein antibody
      • Dipeptidylpeptidase 6 antibody
      • Dipeptidylpeptidase VI antibody
      • DPP VI antibody
      • DPPX antibody
      • VF2 antibody
      see all

    Anti-DPP6 antibody images

    • All lanes : Anti-DPP6 antibody (ab41809) at 1/1000 dilution

      Lane 1 : ESB
      Lane 2 : Mouse Brain
      Lane 3 : DU145 / IL1-beta Lysate
      Lane 4 : DU145 / IL1-beta CM


      Predicted band size : 98 kDa
      Observed band size : 98 kDa
      Additional bands at : 47 kDa (possible truncated form).

    References for Anti-DPP6 antibody (ab41809)

    This product has been referenced in:
    • Sheikh MA  et al. Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells. PLoS One 8:e55826 (2013). WB ; Mouse . Read more (PubMed: 23409053) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"