Overview

  • Product nameAnti-DPYD antibody
    See all DPYD primary antibodies
  • Description
    Rabbit polyclonal to DPYD
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 144 of DPYD

  • Positive control
    • H1299 whole cell lysate. A431, HeLa and HepG2 lysates

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab96496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 111 kDa.

Target

  • FunctionInvolved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • Tissue specificityFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • PathwayAmino-acid biosynthesis; beta-alanine biosynthesis.
  • Involvement in diseaseDefects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • Sequence similaritiesBelongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • DHP antibody
    • DHPDHase antibody
    • Dihydropyrimidine dehydrogenase [NADP(+)] antibody
    • Dihydropyrimidine dehydrogenase [NADP+] antibody
    • Dihydropyrimidine dehydrogenase antibody
    • Dihydrothymine dehydrogenase antibody
    • Dihydrouracil dehydrogenase antibody
    • DPD antibody
    • DPYD antibody
    • DPYD_HUMAN antibody
    • MGC132008 antibody
    • MGC70799 antibody
    • OTTHUMP00000058954 antibody
    see all

Anti-DPYD antibody images

  • Anti-DPYD antibody (ab96496) at 1/500 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 111 kDa

References for Anti-DPYD antibody (ab96496)

ab96496 has not yet been referenced specifically in any publications.

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