Overview

  • Product nameAnti-DPYD antibody
    See all DPYD primary antibodies
  • Description
    Rabbit polyclonal to DPYD
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant fragment corresponding to Human DPYD aa 1-144.
    Database link: Q12882

  • Positive control
    • IHC-P: H358 xenograft tissue. WB: Raji, K562 and NCI-H929 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab96496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 111 kDa.
IHC-P 1/100 - 1/1000.

Target

  • FunctionInvolved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • Tissue specificityFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • PathwayAmino-acid biosynthesis; beta-alanine biosynthesis.
  • Involvement in diseaseDefects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • Sequence similaritiesBelongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • DHP antibody
    • DHPDHase antibody
    • Dihydropyrimidine dehydrogenase [NADP(+)] antibody
    • Dihydropyrimidine dehydrogenase [NADP+] antibody
    • Dihydropyrimidine dehydrogenase antibody
    • Dihydrothymine dehydrogenase antibody
    • Dihydrouracil dehydrogenase antibody
    • DPD antibody
    • DPYD antibody
    • DPYD_HUMAN antibody
    • MGC132008 antibody
    • MGC70799 antibody
    • OTTHUMP00000058954 antibody
    see all

Anti-DPYD antibody images

  • All lanes : Anti-DPYD antibody (ab96496) at 1/1000 dilution

    Lane 1 : Raji whole cell lysate
    Lane 2 : K562 whole cell lysate
    Lane 3 : NCI-H929 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 111 kDa
  • Immunohistochemical analysis of paraffin-embedded H358 xenograft tissue labeling DPYD with ab96496 at 1/500 dilution.

     

References for Anti-DPYD antibody (ab96496)

ab96496 has not yet been referenced specifically in any publications.

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