The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
Use a concentration of 10 µg/ml.
FunctionThe association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Sequence similaritiesBelongs to the NC2 beta/DR1 family. Contains 1 histone-fold domain.
Post-translational modificationsPhosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
ab88597 at 10µg/ml staining DR1 in HeLa cells by Immunofluorescence.
References for Anti-DR1 antibody (ab88597)
This product has been referenced in:
Hsu SF et al. A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication. J Virol89:3671-82 (2015).
Read more (PubMed: 25589657) »
Sun Z et al. Functional divergence of the rapidly evolving miR-513 subfamily in primates. BMC Evol Biol13:255 (2013).
Read more (PubMed: 24252134) »