Overview

  • Product name
    Anti-DR1 antibody - Azide free
    See all DR1 primary antibodies
  • Description
    Chicken polyclonal to DR1 - Azide free
  • Specificity
    This antibody is specific for Hypothetical protein DKFZp666G145.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-176 of Hypothetical protein DKFZp666G145.

  • Positive control
    • Hela cells and 293 cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab37663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Detects a band of approximately 22 kDa (predicted molecular weight: 19 kDa).

Target

  • Function
    The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • Sequence similarities
    Belongs to the NC2 beta/DR1 family.
    Contains 1 histone-fold domain.
  • Post-translational
    modifications
    Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Down regulator of transcription 1 antibody
    • Down regulator of transcription 1 TBP binding antibody
    • Down-regulator of transcription 1 antibody
    • down-regulator of transcription 1, TBP-binding (negative cofactor 2) antibody
    • DR 1 antibody
    • Dr1 antibody
    • Dr1 protein antibody
    • NC 2 antibody
    • NC2 antibody
    • NC2 beta antibody
    • NC2-beta antibody
    • NC2B_HUMAN antibody
    • Negative co factor 2 antibody
    • Negative cofactor 2 antibody
    • Negative cofactor 2 beta antibody
    • Negative cofactor 2-beta antibody
    • Protein Dr1 antibody
    • TATA binding protein associated phosphoprotein antibody
    • TATA box/binding protein associated phosphoprotein DR1 antibody
    • TATA-binding protein-associated phosphoprotein antibody
    see all

Images

  • Lane 1 : Anti-DR1 antibody - Azide free (ab37663) at 1/2000 dilution
    Lanes 2 - 3 : Anti-DR1 antibody - Azide free (ab37663) at 1/500 dilution

    Lane 1 : E coli-derived fusion protein
    Lane 2 : 293 cell line.
    Lane 3 : Hela cells line.

    Secondary
    Goat anti-IgY-HRP. at 1/1000 dilution

    Predicted band size : 19 kDa
    Observed band size : 22 kDa (why is the actual band size different from the predicted?)

References

ab37663 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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