The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Detects a band of approximately 22 kDa (predicted molecular weight: 19 kDa).
FunctionThe association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Sequence similaritiesBelongs to the NC2 beta/DR1 family. Contains 1 histone-fold domain.
Post-translational modificationsPhosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.