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DR2313 (PARP Inhibitor XI)

Product code: ab120368 (formerly Asc-368)

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Overview

Product name

DR2313 (PARP Inhibitor XI)

Description

Potent, brain-penetrant and water-soluble PARP inhibitor

Alternative names

  • PARP Inhibitor XI

Biological description

Potent, brain-penetrant, and water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor. IC50 values are 0.20 and 0.24 µM for PARP-1 and PARP-2 respectively. Neuroprotective in vitro and in vivo.

Purity

> 99%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one

Molecular Weight

182.24

Chemical structure

Chemical Structure

Molecular formula

C8H10N2OS

CAS Number

284028-90-6

Solubility

Soluble in water to 50 mM

Storage instructions

Store at +4°C.

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Polymerase >> PARP >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for DR2313 (PARP Inhibitor XI) (ab120368)

This product has been referenced in:

  • Nakajima H  et al. A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther 312:472-81 (2005).Read more (PubMed: 15466246) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"