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Rabbit polyclonal to DR3
Does not recognise other death receptors.
Mouse, Rat, Human
Synthetic peptide, corresponding to C terminal amino acids 398-417 of Human DR3
(Peptide available as ab8443.)
- Jurkat total cell lysate
A 59 kDa band should bedetected.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||1/500 - 1/1000. Detects a band of approximately 59 kDa.Can be blocked with Human DR3 peptide (ab8443).
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Contains 1 death domain.
Contains 4 TNFR-Cys repeats.
Secreted and Cell membrane.
Information by UniProt
- Apo 3 antibody
- Apo-3 antibody
- Apo3 antibody
References for Anti-DR3 antibody (ab8411)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"