The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa.
FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Tissue specificityWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
Involvement in diseaseSquamous cell carcinoma of the head and neck
Sequence similaritiesContains 1 death domain. Contains 3 TNFR-Cys repeats.
Tumor necrosis factor receptor like protein ZTNFR9 antibody
Tumor necrosis factor receptor superfamily member 10B antibody
Tumor necrosis factor receptor superfamily, member 10b antibody
Anti-DR5 antibody images
Western blot - Anti-DR5 antibody (ab16329)
All lanes : Anti-DR5 antibody (ab16329) at 1/1000 dilution
Lane 1 : HeLa cell lysate Lane 2 : PC12 cell lysate
Lysates/proteins at 25 µg per lane.
Secondary HRP conjugated anti-rabbit Developed using the ECL technique
Predicted band size : 58 kDa Observed band size : 58 kDa
References for Anti-DR5 antibody (ab16329)
This product has been referenced in:
Catlin NR et al. The Stage-specific Testicular Germ Cell Apoptotic Response to Low-dose Radiation and 2,5-hexanedione Combined Exposure. II: qRT-PCR Array Analysis Reveals Dose Dependent Adaptive Alterations in the Apoptotic Pathway. Toxicol PatholN/A:N/A (2014).
Read more (PubMed: 24670816) »