Anti-DR5 antibody [DR5-01-1] (Phycoerythrin) (ab55863)

Overview

  • Product name
    Anti-DR5 antibody [DR5-01-1] (Phycoerythrin)
    See all DR5 primary antibodies
  • Description
    Mouse monoclonal [DR5-01-1] to DR5 (Phycoerythrin)
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Specificity
    This recognizes an extracellular domain of TRAIL R2 (DR5).
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fusion protein of human IgG heavy chain and an extracellular domain of DR5 (TRAIL R2) (Human).

  • Positive control
    • JURKAT human peripheral blood leukemia T cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab55863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use at a concentration of 5.0 µg/ml. This dilution is a recommended starting point for use of this product. Working concentrations should be determined by the end user.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
    • Tissue specificity
      Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
    • Involvement in disease
      Squamous cell carcinoma of the head and neck
    • Sequence similarities
      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Fas like protein antibody
      • Apoptosis inducing protein TRICK2A/2B antibody
      • Apoptosis inducing receptor TRAIL R2 antibody
      • CD262 antibody
      • CD262 antigen antibody
      • Cytotoxic TRAIL receptor 2 antibody
      • Death domain containing receptor for TRAIL/Apo 2L antibody
      • Death receptor 5 antibody
      • DR5 antibody
      • KILLER antibody
      • KILLER/DR5 antibody
      • OTTHUMP00000123492 antibody
      • OTTHUMP00000123493 antibody
      • p53 regulated DNA damage inducible cell death receptor(killer) antibody
      • TNF related apoptosis inducing ligand receptor 2 antibody
      • TNF-related apoptosis-inducing ligand receptor 2 antibody
      • TNFRSF10B antibody
      • TR10B_HUMAN antibody
      • TRAIL R2 antibody
      • TRAIL receptor 2 antibody
      • TRAIL-R2 antibody
      • TRAILR2 antibody
      • TRICK2 antibody
      • TRICK2A antibody
      • TRICK2B antibody
      • TRICKB antibody
      • Tumor necrosis factor receptor like protein ZTNFR9 antibody
      • Tumor necrosis factor receptor superfamily member 10B antibody
      • Tumor necrosis factor receptor superfamily, member 10b antibody
      • ZTNFR9 antibody
      see all

    References for Anti-DR5 antibody [DR5-01-1] (Phycoerythrin) (ab55863)

    ab55863 has not yet been referenced specifically in any publications.

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