• Product nameAnti-DR6 antibody
    See all DR6 primary antibodies
  • Description
    Rabbit polyclonal to DR6
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    corresponding to amino acids 371-655 of Human DR6 (cytoplasmic domain).

  • Positive control
    • Daudi, HeLa, or Jurkat whole cell lysates.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab47180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 66 kDa (predicted molecular weight: 72 kDa).


  • FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • Sequence similaritiesContains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • TNFRSF 21 antibody
    • BM 018 antibody
    • BM018 antibody
    • CD358 antibody
    • Death receptor 6 antibody
    • DR 6 antibody
    • DR6 antibody
    • MGC31965 antibody
    • OTTHUMP00000039915 antibody
    • TNFR related death receptor 6 antibody
    • TNFRSF21 antibody
    • TNFRSF21 protein antibody
    • TNR21_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 21 antibody
    • Tumor necrosis factor receptor superfamily member 21 precursor antibody
    see all

Anti-DR6 antibody images

  • All lanes : Anti-DR6 antibody (ab47180) at 2 µg/ml

    Lane 1 : Total cell lysate from Jurkat cells
    Lane 2 : Total cell lysate from HeLa cells
    Lane 3 : Total cell lysate from Daudi cells

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 72 kDa
    Observed band size : 66 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 33 kDa,36 kDa,60 kDa. We are unsure as to the identity of these extra bands.

References for Anti-DR6 antibody (ab47180)

This product has been referenced in:
  • Klíma M  et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). Read more (PubMed: 19654028) »

See 1 Publication for this product

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