FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Sequence similaritiesContains 1 death domain. Contains 4 TNFR-Cys repeats.
Tumor necrosis factor receptor superfamily member 21 antibody
Tumor necrosis factor receptor superfamily member 21 precursor antibody
Anti-DR6 antibody images
Western blot - DR6 antibody (ab8417)
All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilution
Lane 1 : K562 whole cell lysate with absence of blocking peptide Lane 2 : Raji whole cell lysate with absence of blocking peptide Lane 3 : K562 whole cell lysate with Human DR6 peptide (ab8450) Lane 4 : Raji whole cell lysate with Human DR6 peptide (ab8450)