• Product nameAnti-DR6 antibody [DR-6-04-EC]
    See all DR6 primary antibodies
  • Description
    Mouse monoclonal [DR-6-04-EC] to DR6
  • SpecificityThe antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells but has not been tested on endogenous DR6 therefore we do not guarantee it will work on endogenous DR6.
  • Tested applicationsSuitable for: Flow Cyt, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein, corresponding to extracellular amino acids 42-335 of Human DR6, linked to the Fc portion of human IgG1.

  • Positive control
    • overexpressed DR6 from DR6-transfected HEK/293 cells.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone numberDR-6-04-EC
  • IsotypeIgG1
  • Research areas


Our Abpromise guarantee covers the use of ab14740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 1 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration. Antibody immunoprecipitates overexpressed DR6 from DR6-transfected HEK/293 cells.
ICC/IF Use at an assay dependent concentration.


  • FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
  • Sequence similaritiesContains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • TNFRSF 21 antibody
    • BM 018 antibody
    • BM018 antibody
    • CD358 antibody
    • Death receptor 6 antibody
    • DR 6 antibody
    • DR6 antibody
    • MGC31965 antibody
    • OTTHUMP00000039915 antibody
    • TNFR related death receptor 6 antibody
    • TNFRSF21 antibody
    • TNFRSF21 protein antibody
    • TNR21_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 21 antibody
    • Tumor necrosis factor receptor superfamily member 21 precursor antibody
    see all

Anti-DR6 antibody [DR-6-04-EC] images

  • ab14740 staining DR6 (green) in transiently transfected human Hela cells by ICC/IF. Nuclei were stained with DAPI (blue).

References for Anti-DR6 antibody [DR-6-04-EC] (ab14740)

ab14740 has not yet been referenced specifically in any publications.

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