Anti-DR6 antibody [DR-6-04-EC] (Phycoerythrin) (ab52513)

Overview

  • Product name
    Anti-DR6 antibody [DR-6-04-EC] (Phycoerythrin)
    See all DR6 primary antibodies
  • Description
    Mouse monoclonal [DR-6-04-EC] to DR6 (Phycoerythrin)
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein, corresponding to amino acids 42-335 (extracellular region) of Human DR6 linked to the Fc portion of Human IgG1

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 15mM Sodium Azide
    Constituents: 0.2% BSA, PBS
  • Concentration information loading...
  • Purity
    Size exclusion
  • Purification notes
    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
  • Clonality
    Monoclonal
  • Clone number
    DR-6-04-EC
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab52513 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: A concentration of 10µg/ml is recommended as starting point this product.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
    • Tissue specificity
      Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
    • Sequence similarities
      Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • TNFRSF 21 antibody
      • BM 018 antibody
      • BM018 antibody
      • CD358 antibody
      • Death receptor 6 antibody
      • DR 6 antibody
      • DR6 antibody
      • MGC31965 antibody
      • OTTHUMP00000039915 antibody
      • TNFR related death receptor 6 antibody
      • TNFRSF21 antibody
      • TNFRSF21 protein antibody
      • TNR21_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 21 antibody
      • Tumor necrosis factor receptor superfamily member 21 precursor antibody
      see all

    References

    ab52513 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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