Overview

  • Product nameAnti-DRAM2 antibody
  • Description
    Rabbit polyclonal to DRAM2
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: ISLRVEANLH GLTLYDTAPC PINNERTRLL SRDI, corresponding to C terminal amino acids 233-266 of Human DRAM2.

  • Positive control
    • Human small intestine tissue; Human U 2 OS cells.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab121554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Recommended fixation/permeabilization: PFA/Triton X-100

Target

  • FunctionInduces apoptotic cell death when co-expressed with DRAM1.
  • Tissue specificityExpression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus.
  • Sequence similaritiesBelongs to the DRAM/TMEM150 family.
  • Cellular localizationLysosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2010305N14Rik antibody
    • 2610318G18Rik antibody
    • AI647667 antibody
    • damage regulated autophagy modulator 2 antibody
    • DNA damage regulated autophagy modulator 2 antibody
    • DNA damage regulated autophagy modulator protein 2 antibody
    • DNA damage-regulated autophagy modulator protein 2 antibody
    • Dram2 antibody
    • DRAM2_HUMAN antibody
    • PRO180 antibody
    • PSEC0031 antibody
    • RP5-1180E21.1 antibody
    • Tmem77 antibody
    • Transmembrane protein 77 antibody
    • WWFQ154 antibody
    see all

Anti-DRAM2 antibody images

  • ab121554 at 1/100 dilution staining DRAM2 in Paraffin-embedded Human small intestine tissue by Immunohistochemistry.
    Note: granular cytoplasmic positivity in glandular cells.
  • ab121554 at 4 µg/ml staining DRAM2 in PFA/Triton X-100 fixed/permeabilized U2 OS cells by Immunofluorescence (green).
    Note: positivity in golgi apparatus & vesicles.

References for Anti-DRAM2 antibody (ab121554)

ab121554 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"