Overview

  • Product name
  • Description
    Rabbit polyclonal to DRG2
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen, corresponding to amino acids 210-359 of Human DRG2 (P55039).

  • Positive control
    • Human kidney tissue, Human cell line U-2 OS

Properties

Applications

Our Abpromise guarantee covers the use of ab121268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. pH 6, using a pressure boiler
ICC/IF Use a concentration of 1 - 4 µg/ml. The following steps are recommended prior to antibody incubation: cells fixation in ice cold 4% paraformaldehyde pH 7.2-7.3, followed by permeabilization with 0.1% Triton X-100 in PBS for 3x5 minutes.

Target

  • Function
    May play a role in cell proliferation, differentiation and death.
  • Tissue specificity
    Highest levels in skeletal muscle, heart and kidney. Low levels in colon, thymus, spleen, small intestine, lung and Leukocytes.
  • Sequence similarities
    Belongs to the GTP1/OBG family.
    Contains 1 G (guanine nucleotide-binding) domain.
  • Post-translational
    modifications
    Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with RWDD1.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Developmentally regulated GTP binding protein 2 antibody
    • Developmentally-regulated GTP-binding protein 2 antibody
    • DRG 2 antibody
    • DRG-2 antibody
    • drg2 antibody
    • DRG2_HUMAN antibody
    see all

Images

  • ab121268 at 1/35 dilution staining DRG2 in Human kidney by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab121268 at 4 µg/ml staining DRG2 in Human cell line U-2 OS by Immunofluorescent staining. Antibody staining is shown in green.

References

ab121268 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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