Overview

  • Product name
  • Description
    Rabbit polyclonal to DRIP130
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Horse, Guinea pig, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Zebra finch
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 400-450 of Human DRIP130 (SwissProt Q9ULK4)

  • Positive control
    • Nuclear extract from HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab70449 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
  • Application notes
    IP: Use at 1 - 4 µg/mg of lysate.


    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
    • Sequence similarities
      Belongs to the Mediator complex subunit 23 family.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 130 kDa transcriptional co activator antibody
      • 133 kDa transcriptional co activator antibody
      • Activator recruited cofactor 130 kDa component antibody
      • Activator-recruited cofactor 130 kDa component antibody
      • ARC 130 antibody
      • ARC130 antibody
      • Cofactor required for Sp1 transcriptional activation subunit 3 130kDa antibody
      • Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator antibody
      • Cofactor required for Sp1 transcriptional activation subunit 3 antibody
      • CRSP 130 antibody
      • CRSP 130 kD subunit antibody
      • CRSP 133 antibody
      • CRSP 3 antibody
      • CRSP complex subunit 3 antibody
      • CRSP130 antibody
      • CRSP133 antibody
      • CRSP3 antibody
      • CRSP3 protein antibody
      • DKFZp434H0117 antibody
      • DRIP 130 antibody
      • DRIP130 antibody
      • hSur-2 antibody
      • KIAA1216 antibody
      • MED 23 antibody
      • med23 antibody
      • MED23_HUMAN antibody
      • Mediator complex subunit 23 antibody
      • Mediator of RNA polymerase II transcription subunit 23 antibody
      • MRT18 antibody
      • Protein sur-2 homolog antibody
      • SUR 2 antibody
      • SUR2 antibody
      • Transcriptional co activator CRSP 130 antibody
      • Transcriptional co activator CRSP130 antibody
      • Transcriptional coactivator CRSP130 antibody
      • Vitamin D3 receptor interacting protein antibody
      • Vitamin D3 receptor interacting protein complex 130 kDa component antibody
      • Vitamin D3 receptor-interacting protein complex 130 kDa component antibody
      see all

    Images

    • Detection of Human DRIP130 by Immunoprecipitation in Nuclear extract (5 mg) from HeLa cells using ab70449 at 4 µg/5 mg extract. Detection: Coomassie stain.

    References

    This product has been referenced in:
    • Meyer KD  et al. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 27:1447-57 (2008). Read more (PubMed: 18418385) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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