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ab12286 has been referenced in 55 publications.

  • Hubé F  et al. Short intron-derived ncRNAs. Nucleic Acids Res 45:4768-4781 (2017). WB ; Human . PubMed: 28053119
  • Xu L  et al. Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer. Cell Death Dis 8:e2642 (2017). IHC . PubMed: 28252644
  • Salzman DW  et al. miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage. Nat Commun 7:10954 (2016). WB ; Human . PubMed: 26996824
  • Jiang FZ  et al. Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing. Oncotarget 6:44660-74 (2015). IP . PubMed: 26587974
  • Dhir A  et al. Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nat Struct Mol Biol 22:319-27 (2015). Human . PubMed: 25730776
  • Srinivas C  et al. Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer. PLoS One 10:e0142006 (2015). WB ; Human . PubMed: 26551008
  • Bahn JH  et al. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nat Commun 6:6355 (2015). IP, WB ; Human . PubMed: 25751603
  • Yang Q  et al. Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival. Mol Cell 57:721-34 (2015). PubMed: 25699712
  • Porta S  et al. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. J Neuropathol Exp Neurol 74:380-7 (2015). PubMed: 25756586
  • Kim Y  et al. Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency. Autophagy 11:796-811 (2015). PubMed: 25946189
  • Ghatak S  et al. Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes. Mol Ther 23:1201-1210 (2015). PubMed: 25896246
  • Yuan S  et al. Murine follicular development requires oocyte DICER, but not DROSHA. Biol Reprod 91:39 (2014). PubMed: 24990804
  • Kuchenreuther MJ & Weber JD The ARF tumor-suppressor controls Drosha translation to prevent Ras-driven transformation. Oncogene 33:300-7 (2014). PubMed: 23318441
  • Nachmani D  et al. MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog 10:e1003963 (2014). WB ; Human . PubMed: 24586166
  • Shapiro JS  et al. Drosha as an interferon-independent antiviral factor. Proc Natl Acad Sci U S A 111:7108-13 (2014). PubMed: 24778219
  • Bai B  et al. RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs. PLoS One 9:e107519 (2014). ICC/IF ; Human . PubMed: 25203660
  • Kim KK  et al. Rbfox3 controls the biogenesis of a subset of microRNAs. Nat Struct Mol Biol 21:901-10 (2014). WB, IF ; Mouse . PubMed: 25240799
  • Weng KF  et al. A cytoplasmic RNA virus generates functional viral small RNAs and regulates viral IRES activity in mammalian cells. Nucleic Acids Res 42:12789-805 (2014). WB, FM ; Human . PubMed: 25352551
  • Gromak N  et al. Drosha regulates gene expression independently of RNA cleavage function. Cell Rep 5:1499-510 (2013). WB . PubMed: 24360955
  • Jafarnejad SM  et al. Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma. Mod Pathol 26:902-10 (2013). IHC-P ; Human . PubMed: 23370771
  • Narayanan A  et al. Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA. J Biol Chem 288:20014-33 (2013). Human . PubMed: 23661700
  • Mishra R & Singh SK HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells. J Neurosci 33:5992-6000 (2013). WB ; Human . PubMed: 23554480
  • Bronevetsky Y  et al. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med 210:417-32 (2013). WB ; Mouse . PubMed: 23382546
  • Mattioli C  et al. A competitive regulatory mechanism discriminates between juxtaposed splice sites and pri-miRNA structures. Nucleic Acids Res 41:8680-91 (2013). WB ; Human . PubMed: 23863840
  • Caramuta S  et al. Role of microRNAs and microRNA machinery in the pathogenesis of diffuse large B-cell lymphoma. Blood Cancer J 3:e152 (2013). WB ; Human . PubMed: 24121164
  • Chen YJ  et al. Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. PLoS One 8:e82751 (2013). WB ; Human . PubMed: 24358224
  • Lezina L  et al. miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. Cell Death Dis 4:e953 (2013). ChIP . PubMed: 24336073
  • Sellier C  et al. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome. Cell Rep 3:869-80 (2013). PubMed: 23478018
  • Caramuta S  et al. Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma. Endocr Relat Cancer 20:551-64 (2013). WB . PubMed: 23671264
  • Bellemer C  et al. Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes. J Cell Sci 125:2709-20 (2012). PubMed: 22393237
  • Morlando M  et al. FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J 31:4502-10 (2012). PubMed: 23232809
  • Santamaría C  et al. Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients. Haematologica 97:1218-24 (2012). PubMed: 22371183
  • Chiappinelli KB  et al. Reduced DICER1 elicits an interferon response in endometrial cancer cells. Mol Cancer Res 10:316-25 (2012). WB ; Human . PubMed: 22252463
  • Van Duyne R  et al. Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. PLoS One 7:e40662 (2012). WB, ICC/IF ; Human . PubMed: 22808228
  • Noguchi K  et al. HIV-1 Suppressive Sequences Are Modulated by Rev Transport of Unspliced RNA and Are Required for Efficient HIV-1 Production. PLoS One 7:e51393 (2012). WB . PubMed: 23251516
  • Bornachea O  et al. EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep 2:434 (2012). WB . PubMed: 22666537
  • Ho JJ  et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J Biol Chem 287:29003-20 (2012). WB ; Human . PubMed: 22745131
  • Lu C  et al. P bodies inhibit retrotransposition of endogenous intracisternal a particles. J Virol 85:6244-51 (2011). PubMed: 21525359
  • Li Z  et al. Small RNA-mediated regulation of iPS cell generation. EMBO J 30:823-34 (2011). WB . PubMed: 21285944
  • Coley W  et al. Absence of DICER in monocytes and its regulation by HIV-1. J Biol Chem 285:31930-43 (2010). PubMed: 20584909
  • Danielson LS  et al. A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy. Am J Pathol 177:908-17 (2010). WB ; Human . PubMed: 20558575
  • Yao G  et al. MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol 24:540-51 (2010). WB . PubMed: 20118412
  • Buratti E  et al. Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J 277:2268-81 (2010). WB ; Human . PubMed: 20423455
  • Krol J  et al. Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell 141:618-31 (2010). WB ; Mouse . PubMed: 20478254
  • Tili E  et al. GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials. Nucleic Acids Res 38:7673-88 (2010). WB ; Human . PubMed: 20639536
  • Han J  et al. Posttranscriptional crossregulation between Drosha and DGCR8. Cell 136:75-84 (2009). WB ; Mouse . PubMed: 19135890
  • Guttilla IK & White BA Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem 284:23204-16 (2009). WB ; Human . PubMed: 19574223
  • Yamagata K  et al. Maturation of MicroRNA Is Hormonally Regulated by a Nuclear Receptor. Mol Cell 36:340-7 (2009). WB ; Human, Mouse . PubMed: 19854141
  • Kataoka N  et al. Functional association of the Microprocessor complex with the spliceosome. Mol Cell Biol 29:3243-54 (2009). WB, IP ; Human . PubMed: 19349299
  • Ballarino M  et al. Coupled RNA processing and transcription of intergenic primary microRNAs. Mol Cell Biol 29:5632-8 (2009). ChIP ; Human . PubMed: 19667074
  • Cheng TL  et al. Multitarget therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system. Cancer Gene Ther 16:516-31 (2009). PubMed: 19165234
  • Zhang MX  et al. Biogenesis of short intronic repeat 27nt small RNA from endothelial nitric oxide synthase gene. J Biol Chem : (2008). WB ; Human . PubMed: 18390539
  • Merritt WM  et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 359:2641-50 (2008). PubMed: 19092150
  • Nakamura T  et al. Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing. Proc Natl Acad Sci U S A 104:10980-5 (2007). PubMed: 17581865
  • Aagaard L  et al. A facile lentiviral vector system for expression of doxycycline-inducible shRNAs: knockdown of the pre-miRNA processing enzyme Drosha. Mol Ther 15:938-45 (2007). WB . PubMed: 17311008

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