Overview

  • Product nameAnti-DsbA L antibody
  • Description
    Rabbit polyclonal to DsbA L
  • Specificityab92819 is specific for the ~25 kDa DsbA-L protein in Western blots of 3T3-L1 adipocytes and mouse white and brown adipose tissue lysate samples.
  • Tested applicationsSuitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length Mouse DsbA L protein.

  • Positive control
    • 3T3-L1 adipocytes and Mouse white and brown adipose tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab92819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Detects a band of approximately 25 kDa.
IHC-Fr Use at an assay dependent concentration.

Target

  • RelevanceDisulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.
  • Alternative names
    • DSBA like thioredoxin domain containing protein antibody

Anti-DsbA L antibody images

  • Anti-DsbA L antibody (ab92819) at 1/2000 dilution + Mouse adipose tissue

References for Anti-DsbA L antibody (ab92819)

This product has been referenced in:
  • Jedrychowski MP  et al. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab 4:758-70 (2015). Read more (PubMed: 26629401) »
  • Walker GE  et al. Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One 9:e83685 (2014). WB . Read more (PubMed: 24404137) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab92819.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"