Overview

  • Product nameAnti-DTX2 antibody
    See all DTX2 primary antibodies
  • Description
    Mouse polyclonal to DTX2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-622 of Human DTX2

  • Positive control
    • DTX2 transfected mammalian cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab68070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 67 kDa).

Target

  • FunctionRegulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the Deltex family.
    Contains 1 RING-type zinc finger.
    Contains 2 WWE domains.
  • DomainThe WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Cellular localizationCytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • Deltex 2 antibody
    • deltex homolog 2 (Drosophila) antibody
    • deltex, Drosophila, homolog of, 2 antibody
    • Deltex2 antibody
    • DTX2 antibody
    • DTX2_HUMAN antibody
    • hDTX2 antibody
    • Highly similar to hPMSR6 [H.sapiens] antibody
    • KIAA1528 antibody
    • Probable E3 ubiquitin-protein ligase DTX2 antibody
    • Protein deltex 2 antibody
    • Protein deltex-2 antibody
    • RING finger protein 58 antibody
    • RNF58 antibody
    • Zinc ion binding protein antibody
    see all

Anti-DTX2 antibody images

  • All lanes : Anti-DTX2 antibody (ab68070) at 1/500 dilution

    Lane 1 : DTX2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 67 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)

References for Anti-DTX2 antibody (ab68070)

ab68070 has not yet been referenced specifically in any publications.

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