Overview

  • Product name
  • Description
    Rabbit polyclonal to DTX3L
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 23 and 202 of Human DTX3L (Q8TDB6).

  • Positive control
    • A431, 293T and Jurkat whole cell lysates.
  • General notes
    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab126040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 84 kDa.

Target

  • Function
    Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the Deltex family.
    Contains 1 RING-type zinc finger.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • B lymphoma and BAL associated protein antibody
    • B-lymphoma- and BAL-associated protein antibody
    • BBAP antibody
    • Deltex 3 like antibody
    • DTX 3L antibody
    • DTX3L antibody
    • DTX3L_HUMAN antibody
    • E3 ubiquitin-protein ligase DTX3L antibody
    • Protein deltex 3 like antibody
    • Protein deltex 3 like protein antibody
    • Protein deltex-3-like antibody
    • Rhysin 2 antibody
    • Rhysin-2 antibody
    • Rhysin2 antibody
    see all

Images

  • Anti-DTX3L antibody (ab126040) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 84 kDa

References

ab126040 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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