Overview

  • Product name
  • Description
    Goat polyclonal to DUOX1
  • Host species
    Goat
  • Specificity
    This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human DUOX1 aa 1020-1032 (internal sequence). Synthetic peptide:

    EKFQRSCLHQTVQ

    , corresponding to internal sequence amino acids 1020-1032 of Human DUOX1 (NP_059130.2 ; NP_787954.1)
    Sequence:

    EKFQRSCLHQTVQ


    Database link: Q9NRD9

  • Positive control
    • Human placenta and thyroid gland lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab78919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 6 µg/ml.

Target

  • Relevance
    The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene).
  • Cellular localization
    Cell Membrane
  • Database links
  • Alternative names
    • Dual oxidase 1 antibody
    • Dual oxidase 1 precursor antibody
    • DUOX1 antibody
    • EC 1.11.1 antibody
    • EC 1.6.3.1 antibody
    • Flavoprotein NADPH oxidase antibody
    • Large NOX 1 antibody
    • LNOX1 antibody
    • Long NOX 1 antibody
    • MGC138840 antibody
    • MGC138841 antibody
    • NADPH thyroid oxidase 1 antibody
    • Nicotinamide adenine dinucleotide phosphate oxidase antibody
    • NOXEF1 antibody
    • THOX1 antibody
    • Thyroid oxidase 1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human thyroid gland labeling DUOX1 with ab78919 at 4-6μg/ml. The image shows staining of membranes in epithelial cells of the thyroid gland.

    Steamed antigen retrieval with Tris/EDTA buffer pH 9 was performed. Antibody was detected by HRP-staining.

References

This product has been referenced in:
  • Yang N  et al. LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma. Oncotarget 6:28151-63 (2015). WB . Read more (PubMed: 26305675) »

See 1 Publication for this product

Customer reviews and Q&As

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As you may know, ab78919 is one of our Fast-track antibodies and it is not yet fully characterized. We cannot guarantee that the antibody will work in any application other than ELISA against the immunizing peptid...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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