Overview

  • Product name
  • Description
    Rabbit polyclonal to DUSP26
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, derived from the internal domain of Human DUSP26.

  • Positive control
    • Human liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab115571 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
  • Tissue specificity
    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 tyrosine-protein phosphatase domain.
  • Cellular localization
    Cytoplasm. Nucleus. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DSP-4 antibody
    • Dual specificity phosphatase 26 (putative) antibody
    • Dual specificity phosphatase 26 antibody
    • Dual specificity phosphatase SKRP3 antibody
    • Dual specificity protein phosphatase 26 antibody
    • DUS26_HUMAN antibody
    • DUSP24 antibody
    • DUSP26 antibody
    • Hypothetical protein FLJ31142 antibody
    • LDP 4 antibody
    • LDP-4 antibody
    • Low molecular mass dual specificity phosphatase 4 antibody
    • Low-molecular-mass dual-specificity phosphatase 4 antibody
    • MAP kinase phosphatase 8 antibody
    • MGC1136 antibody
    • MGC2627 antibody
    • Mitogen activated protein kinase phosphatase 8 antibody
    • Mitogen-activated protein kinase phosphatase 8 antibody
    • MKP-8 antibody
    • MKP8 antibody
    • NATA1 antibody
    • NATA1 protein antibody
    • Novel amplified gene in thyroid anaplastic cancer antibody
    • SKRP3 antibody
    see all

Images

  • Human liver (formalin-fixed, paraffin-embedded) stained with ab115571 at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115571 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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