Overview

  • Product name
  • Description
    Rabbit polyclonal to DUSP4
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide from the center region of DUSP4 (Human) conjugated to KLH

  • Positive control
    • Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab60229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
    Contains 1 rhodanese domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dual specificity phosphatase 4 antibody
    • Dual specificity protein phosphatase 4 antibody
    • Dual specificity protein phosphatase hVH2 antibody
    • DUS4_HUMAN antibody
    • DUSP 4 antibody
    • Dusp4 antibody
    • HVH 2 antibody
    • HVH2 antibody
    • MAP kinase phosphatase 2 antibody
    • Mitogen activated protein kinase phosphatase 2 antibody
    • Mitogen-activated protein kinase phosphatase 2 antibody
    • MKP 2 antibody
    • MKP-2 antibody
    • MKP2 antibody
    • Serine/threonine specific protein phosphatase antibody
    • TYP antibody
    • Typ1 antibody
    • VH 2 antibody
    • VH1 homologous phosphatase 2 antibody
    • VH2 antibody
    see all

Images

  • Ab60229 (1:50) staining human DUSP4 in human breast carcinoma tissue by immunohistochemistry using formalin fixed, paraffin embedded tissue.

    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

    BC = breast carcinoma

References

This product has been referenced in:
  • Fancy SP  et al. Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci 17:506-12 (2014). Read more (PubMed: 24609463) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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