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Dynamin Inhibitors: Dynole™ Series Kit

Product code: ab120474 (formerly Asc-474)

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Overview

Product name

Dynamin Inhibitors: Dynole™ Series Kit

Specificity

Convenient kit containing dynamin inhibitor Dynole-34-2™ ab120464; 1mg) from the Dynole chemical series. Dynole-34-2™ targets dynamin at the GTPase Allosteric Site (GAS) domain and inhibits dynamin and endocytosis in enzymatic and cell based assays. The inhibitor and negative control are based on the same chemical scaffold.

Product overview

DynoleTM chemical series collection


Convenient kit containing dynamin inhibitor Dynole-34-2™ (ab120463; 1 mg) and negative control Dynole-31-2™ (ab120464; 1mg) from the Dynole chemical series. Dynole-34-2™ targets dynamin at the GTPase Allosteric Site (GAS) domain and inhibits dynamin and endocytosis in enzymatic and cell based assays. The inhibitor and negative control are based on the same chemical scaffold.























TargetDescription
GTPase Allosteric Site

Dynole-34-2™:


Potent dynamin I and dynamin II inhibitor

GTPase Allosteric Site

Dynole-31-2™:


Negative control for Dynole 34-2™



Notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™, Dynole-31-2™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.

Properties

Storage instructions

Store at +4°C (desiccating conditions). Do not freeze.

Components 1 kit
ab120464 - Dynole-31-2™ 1 x 1mg
ab120463 - Dynole-34-2™ 1 x 1mg

Research areas

Biochemicals >> Research Area >> Stroke >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Obesity >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Hypertension >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Heart disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Diabetes >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Cancer >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Kits

References for Dynamin Inhibitors: Dynole™ Series Kit (ab120474)

This product has been referenced in:

  • Hill TA  et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem 52:3762-73 (2009).Read more (PubMed: 19459681) »

See 1 publication for this product

Publishing research using ab120474? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"