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Dynamin Inhibitors: MiTMAB™ Series Kit

Product code: ab120473 (formerly Asc-473)

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Overview

Product name

Dynamin Inhibitors: MiTMAB™ Series Kit

Specificity

Convenient kit of dynamin inhibitors from the MiTMAB™ chemical series. The inhibitors target dynamin at the lipid binding (PH) domain and inhibit dynamin and endocytosis in enzymatic and cell based assays. They are based on the same chemical scaffold. A negative control compound is also included. Kit contains 1 mg of each of MiTMAB™ ab120476.

Product overview

MiTMABTM chemical series collection


Convenient kit of dynamin inhibitors from the MiTMAB™ chemical series. The inhibitors target dynamin at the lipid binding (PH) domain and inhibit dynamin and endocytosis in enzymatic and cell based assays. They are based on the same chemical scaffold. A negative control compound is also included. Kit contains 1 mg of each of MiTMAB™ (ab120466), OcTMAB™ (ab120467), and Pro-Mystyric Acid™ (ab120476).

Pro-Myristic acid is an in vitro inhibitor of dynamin. Although cell permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor. It can therefore be used as a negative control in cell-based studies.


























TargetDescription
PH lipid binding site

MiTMAB™:


Cell permeable dynamin I and dynamin II inhibitor

PH lipid binding site

OcTMAB™:


Cell permeable dynamin I and dynamin II inhibitor

PH lipid binding site

Pro-Myristic Acid:


Negative control for MiTMAB™ and OcTMAB™

Notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. MiTMAB™ and OcTMAB™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.

Properties

Storage instructions

Store at +4°C (desiccating conditions). Do not freeze.

Components 1 kit
ab120466 - MiTMAB™ 1 x 1mg
ab129467 - OcTMAB™ 1 x 1mg
ab120476 - Pro-Myristic Acid1 x 1mg

Research areas

Biochemicals >> Research Area >> Stroke >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Obesity >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Hypertension >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Heart disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Diabetes >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Cancer >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Signaling >> Endocytosis & exocytosis >> Dynamin
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Kits

References for Dynamin Inhibitors: MiTMAB™ Series Kit (ab120473)

This product has been referenced in:

  • Joshi S  et al. The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther 9:1995-2006 (2010).Read more (PubMed: 20571068) »

See 1 publication for this product

Publishing research using ab120473? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"