Overview

  • Product name
  • Description
    Rabbit polyclonal to DYNC1I2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Zebrafish
  • Immunogen

    Recombinant protein fragment, corresponding to a region within amino acids 129 and 376 of Human DYNC1I2

  • Positive control
    • HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab96288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 71 kDa.

Target

  • Function
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
  • Sequence similarities
    Belongs to the dynein intermediate chain family.
    Contains 7 WD repeats.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR. The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
  • Cellular localization
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytoplasmic dynein 1 intermediate chain 2 antibody
    • Cytoplasmic dynein intermediate chain 2 antibody
    • cytosolic antibody
    • DC1I2_HUMAN antibody
    • DH IC 2 antibody
    • DH IC-2 antibody
    • DNCI2 antibody
    • DNCIC2 antibody
    • Dync1i2 antibody
    • Dynein intermediate chain 2 antibody
    • Dynein intermediate chain 2, cytosolic antibody
    • Dynein, cytoplasmic, intermediate polypeptide 2 antibody
    • IC2 antibody
    see all

Images

  • Anti-DYNC1I2 antibody (ab96288) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 71 kDa

References

This product has been referenced in:
  • Thinon E  et al. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun 5:4919 (2014). Read more (PubMed: 25255805) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96288.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up