Anti-Dynein intermediate chain 1 antibody [70.1] (ab88722)

Overview

  • Product nameAnti-Dynein intermediate chain 1 antibody [70.1]
    See all Dynein intermediate chain 1 primary antibodies
  • Description
    Mouse monoclonal [70.1] to Dynein intermediate chain 1
  • SpecificityDetect cytoplasmic Dynein intermediate chains. Reactivity with the axonemal form is not known.
  • Tested applicationsSuitable for: ELISA, IP, WB, ICC/IF, ICCmore details
  • Species reactivity
    Reacts with: Rat, Chicken, Hamster, Human, Fish, Marsupials, Deer
    Predicted to work with: Amphibians
  • Immunogen

    Cytoplasmic, full length, native Dynein intermediate chain protein purified from Chick brain

Properties

Applications

Our Abpromise guarantee covers the use of ab88722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IP
WB
ICC/IF
ICC
  • Application notesELISA: Use at an assay dependent dilution.
    ICC: Use at an assay dependent dilution.
    ICC/IF: 1/100.
    IP: Use at an assay dependent dilution.
    WB: 1/2000. Detects a ~ 70 kDa triplet.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPart of the dynein complex of respiratory cilia.
    • Involvement in diseaseDefects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1) [MIM:244400]. CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
      Defects in DNAI1 are the cause of Kartagener syndrome (KTGS) [MIM:244400]. KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera).
    • Sequence similaritiesBelongs to the dynein intermediate chain family.
      Contains 5 WD repeats.
    • Cellular localizationCytoplasm > cytoskeleton > cilium axoneme.
    • Information by UniProt
    • Database links
    • Alternative names
      • Axonemal dynein intermediate chain 1 antibody
      • Axonemal dynein intermediate chain 2 antibody
      • CILD 1 antibody
      • CILD1 antibody
      • Cytoplasmic dynein 1 intermediate chain 1 antibody
      • Cytoplasmic dynein 1 intermediate chain 2 antibody
      • Cytoplasmic dynein intermediate chain 1 antibody
      • Cytoplasmic dynein intermediate chain 2 antibody
      • DH IC 1 antibody
      • DH IC 2 antibody
      • DIC1 antibody
      • DNAI 1 antibody
      • DNAI 2 antibody
      • DNAI1 antibody
      • DNAI1_HUMAN antibody
      • DNAI2 antibody
      • DNCI 2 antibody
      • DNCI1 antibody
      • DNCI2 antibody
      • DNCIC 1 antibody
      • DNCIC 2 antibody
      • DNCIC1 antibody
      • DNCIC2 antibody
      • DYNC1I1 antibody
      • DYNC1I2 antibody
      • Dynein axonemal intermediate chain 1 antibody
      • Dynein axonemal intermediate polypeptide 1 antibody
      • Dynein axonemal intermediate polypeptide 2 antibody
      • Dynein cytoplasmic intermediate polypeptide 1 antibody
      • Dynein cytoplasmic intermediate polypeptide 2 antibody
      • Dynein intermediate chain 1 axonemal antibody
      • Dynein intermediate chain 1 cytosolic antibody
      • Dynein intermediate chain 1, axonemal antibody
      • Dynein intermediate chain 2 axonemal antibody
      • Dynein intermediate chain 2 cytosolic antibody
      • Dynein intermediate chain DNAI1 antibody
      • IC74 antibody
      • ICS antibody
      • ICS1 antibody
      • Immotile cilia syndrome 1 antibody
      • MGC26204 antibody
      • PCD antibody
      see all

    References for Anti-Dynein intermediate chain 1 antibody [70.1] (ab88722)

    ab88722 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"