Anti-Dynein intermediate chain 2 antibody (ab72746)

Overview

  • Product nameAnti-Dynein intermediate chain 2 antibody
    See all Dynein intermediate chain 2 primary antibodies
  • Description
    Mouse polyclonal to Dynein intermediate chain 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human Dynein intermediate chain 2 protein (AAH39582).

  • Positive control
    • Dynein intermediate chain 2 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab72746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 69 kDa.

Target

  • FunctionPart of the dynein complex of respiratory cilia.
  • Tissue specificityHighly expressed in trachea and testis.
  • Involvement in diseaseDefects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similaritiesBelongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • Cellular localizationCytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • Database links
  • Alternative names
    • axonemal antibody
    • Axonemal dynein intermediate chain 2 antibody
    • CILD9 antibody
    • DNAI 2 antibody
    • Dnai2 antibody
    • DNAI2_HUMAN antibody
    • Dynein axonemal intermediate chain 2 antibody
    • Dynein axonemal intermediate polypeptide 2 antibody
    • Dynein intermediate chain 2 antibody
    • Dynein intermediate chain 2 axonemal antibody
    see all

Anti-Dynein intermediate chain 2 antibody images

  • All lanes : Anti-Dynein intermediate chain 2 antibody (ab72746) at 1/500 dilution

    Lane 1 : Dynein intermediate chain 2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 69 kDa
    Observed band size : 69 kDa

References for Anti-Dynein intermediate chain 2 antibody (ab72746)

ab72746 has not yet been referenced specifically in any publications.

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