Anti-Dynein intermediate chain 2 antibody (ab96026)

Overview

  • Product nameAnti-Dynein intermediate chain 2 antibody
    See all Dynein intermediate chain 2 primary antibodies
  • Description
    Rabbit polyclonal to Dynein intermediate chain 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 382-605 of Human Dynein intermediate chain 2 (NP_075462).

  • Positive control
    • Molt-4 whole cell lysate; 293T, A431, HepG2, and Raji lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab96026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.

Target

  • FunctionPart of the dynein complex of respiratory cilia.
  • Tissue specificityHighly expressed in trachea and testis.
  • Involvement in diseaseDefects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
  • Sequence similaritiesBelongs to the dynein intermediate chain family.
    Contains 5 WD repeats.
  • Cellular localizationCytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • Database links
  • Alternative names
    • axonemal antibody
    • Axonemal dynein intermediate chain 2 antibody
    • CILD9 antibody
    • DNAI 2 antibody
    • Dnai2 antibody
    • DNAI2_HUMAN antibody
    • Dynein axonemal intermediate chain 2 antibody
    • Dynein axonemal intermediate polypeptide 2 antibody
    • Dynein intermediate chain 2 antibody
    • Dynein intermediate chain 2 axonemal antibody
    see all

Anti-Dynein intermediate chain 2 antibody images

  • Anti-Dynein intermediate chain 2 antibody (ab96026) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

    Predicted band size : 69 kDa

References for Anti-Dynein intermediate chain 2 antibody (ab96026)

ab96026 has not yet been referenced specifically in any publications.

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