• Product name
    Anti-DYNLL1 antibody [AT13C9]
    See all DYNLL1 primary antibodies
  • Description
    Mouse monoclonal [AT13C9] to DYNLL1
  • Host species
  • Tested applications
    Suitable for: WB, Flow Cyt, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Drosophila melanogaster, Cynomolgus monkey
  • Immunogen

    Recombinant full length protein corresponding to Human DYNLL1 aa 1-89. (Purified from E.coli).


    Database link: Q6FGH9

  • Positive control
    • HeLa, A549, 293T and HepG2 cell lysates; A549 cells.
  • General notes

    Clone AT13C9 is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human DYNLL protein.



Our Abpromise guarantee covers the use of ab219259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 10 kDa.
Flow Cyt Use 2-5µg for 106 cells.
ICC/IF 1/100.


  • Function
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
    Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
    Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
  • Tissue specificity
  • Sequence similarities
    Belongs to the dynein light chain family.
  • Post-translational
    Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • Cellular localization
    Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
  • Information by UniProt
  • Database links
  • Alternative names
    • 8 kDa dynein light chain antibody
    • 8kDLC antibody
    • Cytoplasmic dynein light polypeptide antibody
    • DLC1 antibody
    • DLC8 antibody
    • DNCL1 antibody
    • DNCLC1 antibody
    • DYL1_HUMAN antibody
    • Dynein , cytoplasmic, light chain 1 antibody
    • Dynein light chain 1 cytoplasmic antibody
    • Dynein light chain 1, cytoplasmic antibody
    • Dynein light chain LC8 type 1 antibody
    • Dynein light chain LC8-type 1 antibody
    • Dynein, cytoplasmic, light polypeptide 1 antibody
    • Dynein, light chain, LC8-type 1 antibody
    • DYNLL1 antibody
    • HDLC1 antibody
    • LC8 antibody
    • LC8a antibody
    • MGC126137 antibody
    • MGC126138 antibody
    • MGC72986 antibody
    • PIN antibody
    • Protein inhibitor of neuronal nitric oxide synthase antibody
    • Protein inhibitor of neuronal NOS antibody
    see all


  • All lanes : Anti-DYNLL1 antibody [AT13C9] (ab219259) at 1/1000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : A549 cell lysate
    Lane 3 : 293T cell lysate
    Lane 4 : HepG2 cell lysate

    Lysates/proteins at 40 µg per lane.

    All lanes : Goat anti-Mouse secondary antibody conjugated to HRP

    Developed using the ECL technique.

    Predicted band size: 10 kDa

  • Flow cytometric analysis of A549 cells labeling DYNLL1 with ab219259 at 5 µg per 106 cells, followed by Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was Mouse IgG (black line). 

  • Immunofluorescent analysis of A549 cells labeling DYNLL1 with ab219259 at 1/100 dilution, followed by Goat anti-Mouse IgG-Alexa fluor 488 conjugate (green). Cells were counterstained with DAPI (blue) for nucleus staining.


ab219259 has not yet been referenced specifically in any publications.

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