Overview

  • Product name
  • Description
    Rabbit polyclonal to Dynorphin A
  • Specificity
    This antibody blocks with dynorphin 1-17 and 1-8 but not with other related peptides. Cells are found in the paraventricular and supraoptic nucleus and fibers are found in the lateral hypothalamus in rat brain of 4% FA perfused colchicine tissue.
  • Tested applications
    Suitable for: IHC-Fr, IHC-P, RIAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Pig, Rhesus monkey
    Predicted to work with: Guinea pig, Cow
  • Immunogen

    Synthetic peptide:

    YGGFLRRIRPKLKWDNQ

    (Pig).

  • General notes
    This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Whole Serum, PBS
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab11134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/100 - 1/1500.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
RIA 1/10000.

Target

  • Relevance
    Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.
  • Cellular localization
    Secreted
  • Database links
  • Alternative names
    • ADCA antibody
    • Beta neoendorphin dynorphin antibody
    • Dyn A17 antibody
    • leu-enkephalin antibody
    • leumorphin antibody
    • neoendorphin-dynorphin-enkephalin prepropeptide antibody
    • PDYN antibody
    • PENKB antibody
    • Preprodynorphin antibody
    • Proenkephalin B antibody
    • rimorphin antibody
    • SCA23 antibody
    see all

References for Anti-Dynorphin A antibody (ab11134)

This product has been referenced in:
  • Olsen J  et al. Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus. Neuroscience 258:238-45 (2014). Read more (PubMed: 24239719) »
  • Labuz D  et al. Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest 119:278-86 (2009). IHC-Fr ; Mouse . Read more (PubMed: 19139563) »

See all 3 Publications for this product

Product Wall

Thank you for your call yesterday and for your question about these antibodies. I apologize for the delay getting back to you.

We have a general IHC protocol for FFPE sections that includes a section on antigen retrieval-

http://www...

Read More

1. The serum is diluted in PBS, unfortunately we do not have the exact amount that is diluted, however we can estimate the specific antibody concentration to be 0.5-1.0mg/ml. 2. Unfortunately, I have been unsuccessful in locating information to su...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up