• Product nameAnti-DYRK1A antibody
    See all DYRK1A primary antibodies
  • Description
    Rabbit polyclonal to DYRK1A
  • SpecificityThis antibody reacts specifically with 64 kDa of rat DYRK1A. The antibody may cross react with other isoforms from DYRK family.
  • Tested applicationsSuitable for: WB, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Human
  • Immunogen

    Tagged-DYRK1A (rat).

  • General notesVial must be reconstituted with 200 µL of distilled water.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab53231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-Fo: Use at an assay dependent dilution.
    WB: 1/200 - 1/1000. Predicted molecular weight: 86 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
    • Tissue specificityUbiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
    • Involvement in diseaseDefects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
      Contains 1 protein kinase domain.
    • Developmental stageExpressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.
    • DomainThe polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028).
    • Post-translational
      Autophosphorylated on tyrosine residues.
    • Cellular localizationNucleus speckle.
    • Information by UniProt
    • Database links
    • Alternative names
      • Dual specificity tyrosine phosphorylation regulated kinase antibody
      • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A antibody
      • Dual specificity tyrosine phosphorylation regulated kinase 1 antibody
      • Dual specificity tyrosine phosphorylation regulated kinase 1A antibody
      • Dual specificity tyrosine-phosphorylation-regulated kinase 1A antibody
      • Dual specificity YAK 1 related kinase antibody
      • Dual specificity YAK1 related kinase antibody
      • Dual specificity YAK1-related kinase antibody
      • DYR1A_HUMAN antibody
      • DYRK 1 antibody
      • DYRK 1A antibody
      • DYRK antibody
      • DYRK1 antibody
      • Dyrk1a antibody
      • DYRKA antibody
      • hMNB antibody
      • HP 86 antibody
      • HP86 antibody
      • Minibrain (Drosophila) homolog antibody
      • Minibrain homolog antibody
      • Minibrain, Drosophila, homolog of antibody
      • MNB antibody
      • MNB protein kinase antibody
      • Mnb protein kinase homolog hp86 antibody
      • MNB protein kinase, Serine/threonine-specific antibody
      • MNB/DYRK protein kinase antibody
      • MNBH antibody
      • MRD7 antibody
      • OTTHUMP00000109090 antibody
      • OTTHUMP00000109091 antibody
      • OTTHUMP00000109094 antibody
      • OTTHUMP00000174799 antibody
      • Protein kinase minibrain homolog antibody
      • Serine/threonine kinase MNB antibody
      see all

    References for Anti-DYRK1A antibody (ab53231)

    ab53231 has not yet been referenced specifically in any publications.

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