Overview

  • Product nameAnti-Dyrk1B antibody
    See all Dyrk1B primary antibodies
  • Description
    Mouse polyclonal to Dyrk1B
  • SpecificityThis antibody is reactive against mammalian transfected lysate.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Dyrk1B (NP_004705.1, 1 a.a. ~ 629 a.a) full-length human protein.

  • Positive control
    • Transfected 293T cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab69879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 69 kDa).

Target

  • FunctionDual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
  • Tissue specificityHighest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AOMS3 antibody
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1B antibody
    • DYR 1B antibody
    • DYR1A antibody
    • DYR1B antibody
    • DYR1B_HUMAN antibody
    • DYRK 1B antibody
    • Dyrk1b antibody
    • Minibrain related kinase antibody
    • Minibrain-related kinase antibody
    • MIRK antibody
    • Mirk protein kinase antibody
    see all

Anti-Dyrk1B antibody images

  • All lanes : Anti-Dyrk1B antibody (ab69879) at 1/500 dilution

    Lane 1 : Dyrk1B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 69 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

References for Anti-Dyrk1B antibody (ab69879)

ab69879 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"