Overview

  • Product name
  • Description
    Rabbit polyclonal to DYRK2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 520-549 of Mouse DYRK2 (NP_001014412.1).

  • Positive control
    • K562 cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 67 kDa.

Target

  • Function
    Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
  • Tissue specificity
    Testis, after the onset of spermatogenesis.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated on serine/threonine residues.
  • Cellular localization
    Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1810038L18Rik antibody
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 antibody
    • Dual specificity tyrosine phosphorylation regulated kinase 2 antibody
    • Dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody
    • DYRK2 antibody
    • DYRK2_HUMAN antibody
    • EC 2.7.12.1 antibody
    • FLJ21217 antibody
    • FLJ21365 antibody
    see all

Anti-DYRK2 antibody images

  • Anti-DYRK2 antibody (ab116674) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 67 kDa

References for Anti-DYRK2 antibody (ab116674)

ab116674 has not yet been referenced specifically in any publications.

Product Wall

Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
BSA and Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 21°C
Antigen retrieval step
Heat mediated
Sample
Mouse Tissue sections (testis)
Specification
testis
Permeabilization
Yes - 0.1%Triton
Fixative
Paraformaldehyde
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Submitted Mar 04 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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