Overview

  • Product nameAnti-DYRK2 antibody
    See all DYRK2 primary antibodies
  • Description
    Mouse monoclonal to DYRK2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MNDHLHVGSH AHGQIQVQQL FEDNSNKRTV LTTQPNGLTT VGKTGLPVVP ERQLDSIHRR QGSSTSLKSM EGMGKVKATP MTPEQAMKQY MQKLTAFEHH , corresponding to amino acids 1-100 of Human DYRK2

Properties

Applications

Our Abpromise guarantee covers the use of ab56363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRole in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
    • Tissue specificityTestis, after the onset of spermatogenesis.
    • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
      Contains 1 protein kinase domain.
    • Post-translational
      modifications
      Phosphorylated on serine/threonine residues.
    • Cellular localizationCytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1810038L18Rik antibody
      • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody
      • DYRK2 antibody
      • DYRK2_HUMAN antibody
      • EC 2.7.12.1 antibody
      • FLJ21217 antibody
      • FLJ21365 antibody
      see all

    Anti-DYRK2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56363 DYRK2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa
    • Western Blot analysis of DYRK2 expression in transfected 293T cell line by ab56363.

      Lane 1: DYRK2 transfected lysate(59.7 KDa).
      Lane 2: Non-transfected lysate.

    References for Anti-DYRK2 antibody (ab56363)

    ab56363 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"