Overview

  • Product name
    Anti-DYRK3 antibody - N-terminal
    See all DYRK3 primary antibodies
  • Description
    Rabbit polyclonal to DYRK3 - N-terminal
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human DYRK3 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Jurkat cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab72077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 66 kDa (predicted molecular weight: 66 kDa).

Target

  • Function
    Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
  • Tissue specificity
    Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated on tyrosine residues.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 3 antibody
    • Dual specificity tyrosine phosphorylation-regulated kinase 3 antibody
    • Dual specificity tyrosine-phosphorylation-regulated kinase 3 antibody
    • Dyrk3 antibody
    • DYRK3_HUMAN antibody
    • DYRK5 antibody
    • hYAK3 2 antibody
    • Protein kinase Dyrk3 antibody
    • RED antibody
    • REDK antibody
    • Regulatory erythroid kinase antibody
    see all

Images

  • Anti-DYRK3 antibody - N-terminal (ab72077) at 1/1000 dilution + Jurkat cell lysate at 12.5 µg

    Secondary
    HRP-anti-rabbit

    Predicted band size : 66 kDa
    Observed band size : 66 kDa
    Additional bands at : 24 kDa,37 kDa,50 kDa. We are unsure as to the identity of these extra bands.

References

ab72077 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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