Anti-Dystrobrevin alpha antibody (ab112949)

Overview

  • Product nameAnti-Dystrobrevin alpha antibody
    See all Dystrobrevin alpha primary antibodies
  • Description
    Rabbit polyclonal to Dystrobrevin alpha
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 691-721 of Human Dystrobrevin alpha (NP_001381.2, NP_116760.2, NP_116763.1, NP_001382.2, NP_001383.2, NP_116761.2, NP_116757.2 and NP_116762.2).

  • Positive control
    • Mouse heart tissue lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab112949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

Target

  • FunctionMay be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
  • Tissue specificityHighly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
  • Involvement in diseaseDefects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricule with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.
  • Sequence similaritiesBelongs to the dystrophin family. Dystrobrevin subfamily.
    Contains 1 ZZ-type zinc finger.
  • DomainThe coiled coil domain mediates the interaction with dystrophin and utrophin.
  • Post-translational
    modifications
    Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.
  • Cellular localizationCytoplasm. Cell junction > synapse. Cell membrane. In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha-dystrobrevin antibody
    • D18S892E antibody
    • DRP3 antibody
    • DTN antibody
    • DTN-A antibody
    • DTNA antibody
    • DTNA_HUMAN antibody
    • Dystrobrevin alpha antibody
    • Dystrophin related protein 3 antibody
    • Dystrophin-related protein 3 antibody
    • FLJ96209 antibody
    • LVNC1 antibody
    • OTTHUMP00000163151 antibody
    • OTTHUMP00000163152 antibody
    • OTTHUMP00000163153 antibody
    • OTTHUMP00000163154 antibody
    • OTTHUMP00000163155 antibody
    see all

Anti-Dystrobrevin alpha antibody images

  • Anti-Dystrobrevin alpha antibody (ab112949) at 1/100 dilution + Mouse heart tissue lysates at 35 µg

    Predicted band size : 84 kDa

References for Anti-Dystrobrevin alpha antibody (ab112949)

ab112949 has not yet been referenced specifically in any publications.

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