Anti-Dystrobrevin alpha antibody (ab168741)

Overview

  • Product name
    Anti-Dystrobrevin alpha antibody
    See all Dystrobrevin alpha primary antibodies
  • Description
    Mouse polyclonal to Dystrobrevin alpha
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to amino acids 1-371 of Human Dystrobrevin alpha, isoform 9 (AAH05300.1)

  • Positive control
    • Dystrobrevin alpha transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab168741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa.
ICC/IF Use a concentration of 1 µg/ml.

Target

  • Function
    May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
  • Tissue specificity
    Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
  • Involvement in disease
    Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricule with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.
  • Sequence similarities
    Belongs to the dystrophin family. Dystrobrevin subfamily.
    Contains 1 ZZ-type zinc finger.
  • Domain
    The coiled coil domain mediates the interaction with dystrophin and utrophin.
  • Post-translational
    modifications
    Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.
  • Cellular localization
    Cytoplasm. Cell junction > synapse. Cell membrane. In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha-dystrobrevin antibody
    • D18S892E antibody
    • DRP3 antibody
    • DTN antibody
    • DTN-A antibody
    • DTNA antibody
    • DTNA_HUMAN antibody
    • Dystrobrevin alpha antibody
    • Dystrophin related protein 3 antibody
    • Dystrophin-related protein 3 antibody
    • FLJ96209 antibody
    • LVNC1 antibody
    • OTTHUMP00000163151 antibody
    • OTTHUMP00000163152 antibody
    • OTTHUMP00000163153 antibody
    • OTTHUMP00000163154 antibody
    • OTTHUMP00000163155 antibody
    see all

Images

  • All lanes : Anti-Dystrobrevin alpha antibody (ab168741) at 1 µg/ml

    Lane 1 : Dystrobrevin alpha transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

    Predicted band size: 42 kDa

  • Immunofluorescence of 293 cells labeling Dystrobrevin alpha with ab168741 at 1 ug/ml

References

ab168741 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab168741.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up