Anti-Dystrophia myotonica protein kinase antibody (ab183860)

Overview

  • Product name
    Anti-Dystrophia myotonica protein kinase antibody
    See all Dystrophia myotonica protein kinase primary antibodies
  • Description
    Rabbit polyclonal to Dystrophia myotonica protein kinase
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human Dystrophia myotonica protein kinase aa 63-357. The exact sequence is proprietary.
    Database link: Q09013

  • Positive control
    • U87-MG, SK-N-SH and SK-N-AS cell lysates; Mouse prostate tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab183860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
  • Tissue specificity
    Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
  • Involvement in disease
    Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • DM 1 antibody
    • DM antibody
    • DM kinase antibody
    • DM protein kinase antibody
    • DM-kinase antibody
    • DM1 antibody
    • DM1 protein kinase antibody
    • DM1PK antibody
    • DMK antibody
    • DMPK antibody
    • DMPK_HUMAN antibody
    • Dystrophia myotonica 1 antibody
    • Dystrophia myotonica protein kinase antibody
    • MDPK antibody
    • MT PK antibody
    • MT-PK antibody
    • Myotonic dystrophy associated protein kinase antibody
    • Myotonic dystrophy protein kinase antibody
    • Myotonin protein kinase A antibody
    • Myotonin protein kinase antibody
    • Myotonin-protein kinase antibody
    • Thymopoietin homolog antibody
    see all

Images

  • All lanes : Anti-Dystrophia myotonica protein kinase antibody (ab183860) at 1/1000 dilution

    Lane 1 : U-87 MG whole cell lysate/extract
    Lane 2 : SK N SH whole cell lysate/extract
    Lane 3 : SK N AS whole cell lysate/extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 69 kDa

  • Immunohistochemical analysis of, paraffin-embedded mouse prostate tissue, labeling Dystrophia myotonica protein kinase using ab183860 at a 1/500 dilution.

References

ab183860 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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