Anti-Dystrophia myotonica protein kinase antibody (ab54731)

Overview

  • Product nameAnti-Dystrophia myotonica protein kinase antibody
    See all Dystrophia myotonica protein kinase primary antibodies
  • Description
    Mouse monoclonal to Dystrophia myotonica protein kinase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 303-421 of Human Dystrophia myotonica protein kinase

Properties

Applications

Our Abpromise guarantee covers the use of ab54731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCritical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
    • Tissue specificityMost isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
    • Involvement in diseaseDefects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
    • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 protein kinase domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • DM 1 antibody
      • DM antibody
      • DM kinase antibody
      • DM protein kinase antibody
      • DM-kinase antibody
      • DM1 antibody
      • DM1 protein kinase antibody
      • DM1PK antibody
      • DMK antibody
      • DMPK antibody
      • DMPK_HUMAN antibody
      • Dystrophia myotonica 1 antibody
      • Dystrophia myotonica protein kinase antibody
      • MDPK antibody
      • MT PK antibody
      • MT-PK antibody
      • Myotonic dystrophy associated protein kinase antibody
      • Myotonic dystrophy protein kinase antibody
      • Myotonin protein kinase A antibody
      • Myotonin protein kinase antibody
      • Myotonin-protein kinase antibody
      • Thymopoietin homolog antibody
      see all

    Anti-Dystrophia myotonica protein kinase antibody images

    • Western blot against tagged recombinant protein immunogen using ab54731 Dystrophia myotonica protein kinase antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-Dystrophia myotonica protein kinase antibody (ab54731)

    ab54731 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab54731.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"