Overview

  • Product nameAnti-DYX1C1 antibody
    See all DYX1C1 primary antibodies
  • Description
    Goat polyclonal to DYX1C1
  • Specificityab81986 is expected to recognize three reported isoforms (NP_570722.2, NP_001028731.1 and NP_001028732.1).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide:

    PLQVSDYSWQQTKT-C

    , corresponding to N terminal amino acids 2-15 of human DYX1C1 (NP_570722.2; NP_001028731.1; NP_001028732.1).

  • Positive control
    • Human brain (cerebral cortex and frontal cortex) lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab81986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
    • Tissue specificityExpressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
    • Involvement in diseaseDefects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
    • Sequence similaritiesContains 1 CS domain.
      Contains 3 TPR repeats.
    • Cellular localizationNucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Dyslexia susceptibility 1 candidate 1 antibody
      • Dyslexia susceptibility 1 candidate gene 1 protein antibody
      • DYX1 antibody
      • DYX1C1 antibody
      • DYXC1 antibody
      • DYXC1_HUMAN antibody
      • EKN1 antibody
      • FLJ37882 antibody
      • MGC70618 antibody
      • RD antibody
      see all

    Anti-DYX1C1 antibody images

    • Anti-DYX1C1 antibody (ab81986) at 0.5 µg/ml + human brain (frontal cortex) lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 48 kDa
      Observed band size : 48 kDa
      Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-DYX1C1 antibody (ab81986)

    ab81986 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"