Overview

  • Product nameE-4031 dihydrochloride
  • Description
    HERG K+ channel blocker
  • Alternative names
    • E4031
  • Biological descriptionType III antiarrhythmic drug that blocks ion channels encoded by the ether-a-go-go related gene (ERG1 or KCNH1). Blocks channels in the open configuration with little effect on the channels in the closed configuration. The IC50 for block of human ERG channels in expression systems is approx. 350 nM.
  • Purity> 99%

Properties

    References for E-4031 dihydrochloride (ab120158)

    This product has been referenced in:
    • Kamiya K  et al. Molecular determinants of HERG channel block. Mol Pharmacol 69:1709-16 (2006). Read more (PubMed: 16474003) »
    • Herzberg IM  et al. Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J Physiol 511 ( Pt 1):3-14 (1998). Read more (PubMed: 9679158) »
    • Spector PS  et al. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circ Res 78:499-503 (1996). Read more (PubMed: 8593709) »
    • Sanguinetti MC & Jurkiewicz NK Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96:195-215 (1990). Read more (PubMed: 2170562) »

    See 1 Publication for this product

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