Overview

  • Product name
  • Description
    Rabbit polyclonal to E2F8
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 429-696 of Human E2F8 (UniProt A0AVK6).

  • Positive control
    • A431 and HepG2 whole cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab126163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 94 kDa.

Target

  • Function
    Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.
  • Sequence similarities
    Belongs to the E2F/DP family.
  • Domain
    Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • E2F 8 antibody
    • E2F family member 82 antibody
    • E2F transcription factor 8 antibody
    • E2F-8 antibody
    • E2f8 antibody
    • E2F8_HUMAN antibody
    • FLJ23311 antibody
    • Transcription factor E2F8 antibody
    see all

Images

  • All lanes : Anti-E2F8 antibody (ab126163) at 1/500 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : HepG2 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 94 kDa

References

ab126163 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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