Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab155511)

Overview

  • Product name
    Anti-E3 ubiquitin-protein ligase MUL1 antibody
    See all E3 ubiquitin-protein ligase MUL1 primary antibodies
  • Description
    Rabbit polyclonal to E3 ubiquitin-protein ligase MUL1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 1-352 of Human E3 ubiquitin-protein ligase MUL1 (UniProt Q969V5).

  • Positive control
    • 293T, A431 and Raji cell lysates; A431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab155511 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
  • Tissue specificity
    Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
  • Pathway
    Protein modification; protein ubiquitination.
    Protein modification; protein sumoylation.
  • Sequence similarities
    Contains 1 RING-type zinc finger.
  • Domain
    The zinc finger domain is required for E3 ligase activity.
  • Cellular localization
    Mitochondrion outer membrane. Peroxisome. Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 0610009K11Rik antibody
    • AV000801 antibody
    • C1orf166 antibody
    • Chromosome 1 open reading frame 166 antibody
    • E3 SUMO-protein ligase MUL1 antibody
    • E3 ubiquitin ligase antibody
    • E3 ubiquitin protein ligase MUL1 antibody
    • E3 ubiquitin-protein ligase MUL1 antibody
    • FLJ12875 antibody
    • GIDE antibody
    • Growth inhibition and death E3 ligase antibody
    • MAPL antibody
    • Mitochondrial anchored protein ligase antibody
    • mitochondrial E3 ubiquitin ligase 1 antibody
    • mitochondrial E3 ubiquitin protein ligase 1 antibody
    • Mitochondrial ubiquitin ligase activator of NFKB 1 antibody
    • Mitochondrial-anchored protein ligase antibody
    • MUL1 antibody
    • MUL1_HUMAN antibody
    • MULAN antibody
    • Putative NF kappa B activating protein 266 antibody
    • Putative NF-kappa-B-activating protein 266 antibody
    • RGD1309944 antibody
    • RING finger protein 218 antibody
    • RNF218 antibody
    • RP11-401M16.2 antibody
    • RP23-25C1.10-002 antibody
    see all

Images

  • Confocal immunofluorescent analysis of methanol-fixed A431 cells labeling E3 ubiquitin-protein ligase MUL1 with ab155511 at 1/500 dilution (Green). Alpha-tubulin filaments are labeled red.
  • Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab155511) at 1/2000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 40 kDa



    10% SDS PAGE

References

ab155511 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab155511.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up