Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab99096)

Overview

  • Product nameAnti-E3 ubiquitin-protein ligase MUL1 antibody
    See all E3 ubiquitin-protein ligase MUL1 primary antibodies
  • Description
    Rabbit polyclonal to E3 ubiquitin-protein ligase MUL1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide, corresponding to a region within internal amino acids 143-192 (KPLDSVDLGL ETVYEKFHPS IQSFTDVIGH YISGERPKGI QETEEMLKVG) of Human E3 ubiquitin-protein ligase MUL1 (NP_078820).

  • Positive control
    • THP1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionExhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
  • Tissue specificityWidely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
  • PathwayProtein modification; protein ubiquitination.
    Protein modification; protein sumoylation.
  • Sequence similaritiesContains 1 RING-type zinc finger.
  • DomainThe zinc finger domain is required for E3 ligase activity.
  • Cellular localizationMitochondrion outer membrane. Peroxisome. Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • 0610009K11Rik antibody
    • AV000801 antibody
    • C1orf166 antibody
    • Chromosome 1 open reading frame 166 antibody
    • E3 SUMO-protein ligase MUL1 antibody
    • E3 ubiquitin ligase antibody
    • E3 ubiquitin protein ligase MUL1 antibody
    • E3 ubiquitin-protein ligase MUL1 antibody
    • FLJ12875 antibody
    • GIDE antibody
    • Growth inhibition and death E3 ligase antibody
    • MAPL antibody
    • Mitochondrial anchored protein ligase antibody
    • mitochondrial E3 ubiquitin ligase 1 antibody
    • mitochondrial E3 ubiquitin protein ligase 1 antibody
    • Mitochondrial ubiquitin ligase activator of NFKB 1 antibody
    • Mitochondrial-anchored protein ligase antibody
    • MUL1 antibody
    • MUL1_HUMAN antibody
    • MULAN antibody
    • Putative NF kappa B activating protein 266 antibody
    • Putative NF-kappa-B-activating protein 266 antibody
    • RGD1309944 antibody
    • RING finger protein 218 antibody
    • RNF218 antibody
    • RP11-401M16.2 antibody
    • RP23-25C1.10-002 antibody
    see all

Anti-E3 ubiquitin-protein ligase MUL1 antibody images

  • Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab99096) at 1 µg/ml + THP1 cell lysate at 1 µg

    Predicted band size : 40 kDa

References for Anti-E3 ubiquitin-protein ligase MUL1 antibody (ab99096)

ab99096 has not yet been referenced specifically in any publications.

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