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Anti-eIF4EBP1 antibody [554R16] (ab37225)

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Overview

Product name

Anti-eIF4EBP1 antibody [554R16]
See all eIF4EBP1 products (21) ...

Description

Mouse monoclonal [554R16] to eIF4EBP1

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Recombinant human eIF4EBP1 protein expressed in E. coli.

Positive control

Human HEK293 cells, mouse 3T3-L1 cells and rat L6 cells.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

Purified from ascites by affinity chromatography.

Clonality

Monoclonal

Clone number

554R16

Isotype

IgG1

Light chain type

kappa

Research areas

Epigenetics and Nuclear Signaling >> RNAi >> Eukaryotic Initiation factors (eIF's)
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> RNAi
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Applications

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Our Abpromise guarantee covers the use of ab37225 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 13 kDa.

Target

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Sequence similarities

Belongs to the eIF4E-binding protein family.

Post-translational
modifications

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.

Target information above from: UniProt accessionQ13541 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 4E BP1 antibody
  • 4E-BP1 antibody
  • 4EBP1 antibody
  • 4EBP1_HUMAN antibody
  • BP 1 antibody
  • BP1 antibody
  • eIF4E binding protein 1 antibody
  • eIF4E-binding protein 1 antibody
  • Eif4ebp1 antibody
  • Eukaryotic translation initiation factor 4E binding protein 1 antibody
  • Eukaryotic translation initiation factor 4E-binding protein 1 antibody
  • MGC4316 antibody
  • PHAS I antibody
  • PHAS-I antibody
  • PHASI antibody
  • Phosphorylated heat and acid stable protein regulated by insulin 1 antibody
  • Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
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Database links

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References for Anti-eIF4EBP1 antibody [554R16] (ab37225)

ab37225 has not yet been referenced specifically in any publications.

Publishing research using ab37225? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"