You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

eIF4EBP1 peptide (ab39917)

CodeSizePriceAbpointsAvailability
    
Add to basket
 

  • -

  •   
  •   
  •   

  •  

  •  
  •  

  •  

  •  
Updating...

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »

Overview

Product name

eIF4EBP1 peptide
See all eIF4EBP1 products (5) ...

Protein description

14 amino acid synthetic peptide near the carboxy-terminus of Human eIF4EBP1. This peptide was used as an immunogen for ab25872 - eIF4EBP1 antibody.

Properties

Purification notes

60-70% purity.

Biological activity

blocking the activity of RPS6K1 antibody (ab25872).

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> RNAi >> Eukaryotic Initiation factors (eIF's)
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> RNAi
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Applications

Show applications key

Our Abpromise guarantee covers the use of ab39917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Blocking

     

Application notes

BL: Use at an assay dependent dilution.

This peptide usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

Sequence similarities

Belongs to the eIF4E-binding protein family.

Post-translational
modifications

Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.

Target information above from: UniProt accessionQ13541 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for eIF4EBP1 peptide (ab39917)

ab39917 has not yet been referenced specifically in any publications.

Publishing research using ab39917? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"